Description

Clomid (Clomiphene Citrate) is an estrogen blocker much like Nolvadex. While it has been claimed that Clomid “stimulates” production of leutenizing hormone and follicle stimulating hormone and therefore of testosterone, in fact Clomid’s activity is achieved not by stimulation of the hypothalamus and pituitary, but by blocking their inhibition by estrogen. Clomid is a activator/blocker which, when bound to the estrogen receptor, puts it in a somewhat different conformation (shape) than does estradiol. The estrogen receptor requires binding of an estrogen or drug at its binding site and also the binding of any of several cofactors at different sites. Without the binding of the cofactor, the estrogen receptor is inactive. Different tissues use different cofactors.

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